Opaleye Management Inc. — SEC Form 4 filings
SEC reporting owner CIK 1595855. 117 Form 4 filings on record with FilingPulse; latest filed 2026-09-16.
Transaction summary — filings shown
Covers the 50 most recent of 117 filings on record, filed 2025-12-31 to 2026-09-16. Counts and totals are arithmetic on values as filed — descriptive data, not a recommendation.
- Open-market purchases (code P, non-derivative): 91 legs across 41 filings — 1,283,354 shares, $17,733,781 total (shares × price as filed).
- Open-market sales (code S, non-derivative): 26 legs across 9 filings — 529,585 shares, $18,265,136 total (shares × price as filed).
- Other reported legs (grants, option exercises, tax withholding, gifts, derivative-security transactions, …): 0.
- Largest priced transaction: sale of 134,000 shares @ $39.67 ($5,316,061) in HARROW, INC., filed 2026-03-05.
By issuer — same filings
Open-market purchase/sale legs on non-derivative securities, grouped by issuer. Role is as filed on the newest filing for that issuer. Dollar totals cover priced legs only (shares × price as filed). Ordered by priced transaction value, largest first.
| Issuer | Role (as filed) | Filings | Purchases (P) | Sales (S) | Other legs |
|---|---|---|---|---|---|
| Sol-Gel Technologies Ltd. (SLGL) | 10% owner | 18 | 37 legs · 177,476 sh · $10,459,300 | — | — |
| HARROW, INC. (HROW) | 10% owner | 3 | — | 6 legs · 223,572 sh · $9,184,240 | — |
| Alpha Cognition Inc. (ACOG) | 10% owner | 21 | 51 legs · 1,079,041 sh · $7,218,380 | — | — |
| Eton Pharmaceuticals, Inc. (ETON) | 10% owner | 3 | — | 9 legs · 183,315 sh · $6,894,703 | — |
| SANUWAVE Health, Inc. (SNWV) | 10% owner | 3 | — | 11 legs · 122,698 sh · $2,186,193 | — |
| Grace Therapeutics, Inc. (GRCE) | 10% owner | 2 | 3 legs · 26,837 sh · $56,102 | — | — |
Form 4 filings — Opaleye Management Inc.
| Filed | Form | Issuer | Reported transactions | Source |
|---|---|---|---|---|
| 2026-09-16 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 40,373 @ $8.70 · Purchase (P): 3,375 @ $8.54 · Purchase (P): 53,029 @ $8.57 · Purchase (P): 27,141 @ $8.40 | EDGAR |
| 2026-09-14 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 1,631 @ $66.80 · Purchase (P): 1,493 @ $65.94 | EDGAR |
| 2026-09-10 | 4 | Grace Therapeutics, Inc. (GRCE) | Purchase (P): 9,393 @ $2.10 · Purchase (P): 5,836 @ $2.09 | EDGAR |
| 2026-09-09 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 918 @ $69.52 · Purchase (P): 2,100 @ $68.98 · Purchase (P): 3,390 @ $68.74 · Purchase (P): 471 @ $69.37 · Purchase (P): 3,097 @ $68.70 | EDGAR |
| 2026-09-03 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 783 @ $69.52 · Purchase (P): 900 @ $68.95 | EDGAR |
| 2026-08-31 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 10,000 @ $71.40 · Purchase (P): 20,113 @ $68.42 · Purchase (P): 5,000 @ $68.81 · Purchase (P): 5,000 @ $68.23 · Purchase (P): 217 @ $69.10 | EDGAR |
| 2026-08-19 | 4 | Grace Therapeutics, Inc. (GRCE) | Purchase (P): 11,608 @ $2.09 | EDGAR |
| 2026-08-14 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 951 @ $71.50 | EDGAR |
| 2026-08-04 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 2,900 @ $7.92 · Purchase (P): 50,000 @ $8 | EDGAR |
| 2026-07-28 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 130 @ $7.90 | EDGAR |
| 2026-07-24 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 140,237 @ $7.83 · Purchase (P): 10,000 @ $7.83 · Purchase (P): 49,849 @ $7.80 | EDGAR |
| 2026-07-17 | 4/A | Eton Pharmaceuticals, Inc. (ETON) | Sale (S): 15,000 @ $37.54 · Sale (S): 13,315 @ $37.54 | EDGAR |
| 2026-07-16 | 4 | Eton Pharmaceuticals, Inc. (ETON) | Sale (S): 15,000 @ $37.54 · Sale (S): 13,315 @ $37.54 | EDGAR |
| 2026-07-15 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 775 @ $73.89 · Purchase (P): 920 @ $73.43 | EDGAR |
| 2026-07-10 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 300 @ $73.69 · Purchase (P): 229 @ $73.95 | EDGAR |
| 2026-07-07 | 4 | Eton Pharmaceuticals, Inc. (ETON) | Sale (S): 65,000 @ $37.39 · Sale (S): 25,000 @ $37.39 · Sale (S): 10,000 @ $38 · Sale (S): 20,000 @ $38.37 · Sale (S): 6,685 @ $38.37 | EDGAR |
| 2026-07-02 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 312 @ $71.99 · Purchase (P): 1,400 @ $71.97 | EDGAR |
| 2026-06-29 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 197 @ $6.50 · Purchase (P): 152,336 @ $6.40 | EDGAR |
| 2026-06-15 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 2,862 @ $5.91 · Purchase (P): 273 @ $5.93 · Purchase (P): 4,550 @ $5.99 | EDGAR |
| 2026-06-11 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 24,856 @ $5.98 · Purchase (P): 5,872 @ $5.99 | EDGAR |
| 2026-06-09 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 10,054 @ $5.83 | EDGAR |
| 2026-05-29 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 1,161 @ $5.73 · Purchase (P): 2,000 @ $5.83 · Purchase (P): 70,577 @ $5.90 | EDGAR |
| 2026-05-22 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 8,431 @ $5.89 · Purchase (P): 15,945 @ $5.70 | EDGAR |
| 2026-05-22 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 1,563 @ $64.43 | EDGAR |
| 2026-05-19 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 16,648 @ $5.83 · Purchase (P): 17,395 @ $5.69 | EDGAR |
| 2026-05-14 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 1,500 @ $67.98 · Purchase (P): 1,937 @ $66.87 | EDGAR |
| 2026-05-04 | 4 | SANUWAVE Health, Inc. (SNWV) | Sale (S): 24,000 @ $16.15 · Sale (S): 1,000 @ $16.15 · Sale (S): 10,081 @ $16.11 · Sale (S): 500 @ $16.11 | EDGAR |
| 2026-04-30 | 4 | SANUWAVE Health, Inc. (SNWV) | Sale (S): 43,788 @ $18.47 · Sale (S): 2,500 @ $18.47 · Sale (S): 23,360 @ $17.25 · Sale (S): 1,000 @ $17.25 | EDGAR |
| 2026-04-21 | 4 | SANUWAVE Health, Inc. (SNWV) | Sale (S): 11,267 @ $20.46 · Sale (S): 5,000 @ $20.46 · Sale (S): 202 @ $20.50 | EDGAR |
| 2026-03-31 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 10,000 @ $5.08 · Purchase (P): 1,850 @ $4.99 | EDGAR |
| 2026-03-26 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 4,182 @ $5.59 · Purchase (P): 8,581 @ $5.43 · Purchase (P): 7,319 @ $5.28 | EDGAR |
| 2026-03-24 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 34,665 @ $72 · Purchase (P): 5,000 @ $72 | EDGAR |
| 2026-03-20 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 2,481 @ $5.75 · Purchase (P): 2,094 @ $5.71 | EDGAR |
| 2026-03-18 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 1,331 @ $5.78 | EDGAR |
| 2026-03-13 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 5,708 @ $5.85 · Purchase (P): 7,358 @ $5.75 | EDGAR |
| 2026-03-10 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 1,900 @ $5.80 · Purchase (P): 2,179 @ $5.85 | EDGAR |
| 2026-03-06 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 19,795 @ $5.81 · Purchase (P): 42,023 @ $5.80 · Purchase (P): 5,000 @ $5.80 | EDGAR |
| 2026-03-05 | 4 | HARROW, INC. (HROW) | Sale (S): 59,000 @ $39.15 · Sale (S): 1,309 @ $39.15 · Sale (S): 134,000 @ $39.67 · Sale (S): 4,263 @ $39.67 | EDGAR |
| 2026-03-04 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 20,000 @ $5.80 · Purchase (P): 46,411 @ $5.75 · Purchase (P): 5,000 @ $5.75 | EDGAR |
| 2026-03-03 | 4 | HARROW, INC. (HROW) | Sale (S): 5,000 @ $54.18 | EDGAR |
| 2026-03-02 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 590 @ $5.99 · Purchase (P): 3,638 @ $5.99 | EDGAR |
| 2026-02-24 | 4 | Alpha Cognition Inc. (ACOG) | Purchase (P): 10,000 @ $5.84 · Purchase (P): 2,819 @ $5.84 · Purchase (P): 95,819 @ $5.89 · Purchase (P): 4,181 @ $5.89 · Purchase (P): 53,591 @ $5.80 · Purchase (P): 5,000 @ $5.80 | EDGAR |
| 2026-02-18 | 4/A | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 100 @ $58 | EDGAR |
| 2026-02-18 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 291 @ $63 | EDGAR |
| 2026-02-04 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 100 @ $58 | EDGAR |
| 2026-01-29 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 100 @ $57.05 | EDGAR |
| 2026-01-23 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 2,173 @ $56.57 · Purchase (P): 1,151 @ $55.98 | EDGAR |
| 2026-01-08 | 4 | HARROW, INC. (HROW) | Sale (S): 20,000 @ $53.35 | EDGAR |
| 2026-01-06 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 2,394 @ $41.92 · Purchase (P): 198 @ $42.98 | EDGAR |
| 2025-12-31 | 4 | Sol-Gel Technologies Ltd. (SLGL) | Purchase (P): 8,638 @ $41.85 · Purchase (P): 35,169 @ $41.99 · Purchase (P): 22,497 @ $41.99 | EDGAR |
FilingPulse's Form 4 archive currently extends back to 2024-01-11 and is expanding backward through EDGAR history — earlier filings by this insider may not be indexed yet. Names and roles are shown as filed.
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