Manke Isaac — SEC Form 4 filings
SEC reporting owner CIK 1622769. 16 Form 4 filings on record with FilingPulse; latest filed 2026-09-04.
Transaction summary — filings shown
Covers all 16 filings on record, filed 2024-03-27 to 2026-09-04. Counts and totals are arithmetic on values as filed — descriptive data, not a recommendation.
- Open-market purchases (code P, non-derivative): none reported.
- Open-market sales (code S, non-derivative): none reported.
- Other reported legs (grants, option exercises, tax withholding, gifts, derivative-security transactions, …): 27.
By issuer — same filings
Open-market purchase/sale legs on non-derivative securities, grouped by issuer. Role is as filed on the newest filing for that issuer. Dollar totals cover priced legs only (shares × price as filed). Ordered by priced transaction value, largest first.
| Issuer | Role (as filed) | Filings | Purchases (P) | Sales (S) | Other legs |
|---|---|---|---|---|---|
| Q32 Bio Inc. (QTTB) | Director | 7 | — | — | 14 |
| OnKure Therapeutics, Inc. (OKUR) | Director | 8 | — | — | 9 |
| Addex Therapeutics Ltd. (ADXN) | Director | 1 | — | — | 4 |
Form 4 filings — Manke Isaac
| Filed | Form | Issuer | Reported transactions | Source |
|---|---|---|---|---|
| 2026-09-04 | 4 | Addex Therapeutics Ltd. (ADXN) | Disposition to issuer (D): 219,561 @ $0 · Grant/award (A): 219,561 @ $0 · Disposition to issuer (D): 50,000 (derivative) @ $0 · Grant/award (A): 50,000 (derivative) @ $0 | EDGAR |
| 2026-08-13 | 4/A | OnKure Therapeutics, Inc. (OKUR) | Holdings only — no transactions reported | EDGAR |
| 2026-08-11 | 4 | OnKure Therapeutics, Inc. (OKUR) | Grant/award (A): 300,000 (derivative) @ $0 · Disposition to issuer (D): 15,300 (derivative) · Grant/award (A): 15,300 (derivative) | EDGAR |
| 2026-07-21 | 4/A | Q32 Bio Inc. (QTTB) | Grant/award (A): 10,826 (derivative) @ $0 | EDGAR |
| 2026-07-02 | 4 | Q32 Bio Inc. (QTTB) | Option exercise (M): 53,521 @ $2.80 · Option exercise (M): 53,521 (derivative) @ $0 | EDGAR |
| 2026-06-16 | 4 | Q32 Bio Inc. (QTTB) | Grant/award (A): 9,810 (derivative) @ $0 | EDGAR |
| 2026-01-02 | 4 | OnKure Therapeutics, Inc. (OKUR) | Grant/award (A): 5,258 @ $0 | EDGAR |
| 2025-10-27 | 4 | Q32 Bio Inc. (QTTB) | Grant/award (A): 53,521 (derivative) @ $0 | EDGAR |
| 2025-10-02 | 4 | OnKure Therapeutics, Inc. (OKUR) | Grant/award (A): 5,545 @ $0 | EDGAR |
| 2025-07-02 | 4 | OnKure Therapeutics, Inc. (OKUR) | Grant/award (A): 6,311 @ $0 | EDGAR |
| 2025-05-30 | 4 | OnKure Therapeutics, Inc. (OKUR) | Grant/award (A): 7,650 (derivative) @ $0 | EDGAR |
| 2025-04-02 | 4 | OnKure Therapeutics, Inc. (OKUR) | Grant/award (A): 3,469 @ $0 | EDGAR |
| 2025-02-27 | 4 | Q32 Bio Inc. (QTTB) | Disposition to issuer (D): 12,767 (derivative) @ $0 · Grant/award (A): 12,767 (derivative) @ $0 · Disposition to issuer (D): 2,627 (derivative) @ $0 · Grant/award (A): 2,627 (derivative) @ $0 · Grant/award (A): 19,008 (derivative) @ $0 · Disposition to issuer (D): 19,008 (derivative) @ $0 · +1 more | EDGAR |
| 2024-10-08 | 4 | OnKure Therapeutics, Inc. (OKUR) | Grant/award (A): 15,300 (derivative) @ $0 | EDGAR |
| 2024-09-30 | 4 | Q32 Bio Inc. (QTTB) | Grant/award (A): 2,627 (derivative) @ $13.42 | EDGAR |
| 2024-03-27 | 4 | Q32 Bio Inc. (QTTB) | Grant/award (A): 12,767 (derivative) @ $0 | EDGAR |
FilingPulse's Form 4 archive currently extends back to 2024-01-11 and is expanding backward through EDGAR history — earlier filings by this insider may not be indexed yet. Names and roles are shown as filed.
Need this as JSON?
GET https://api.filingpulse.io/v1/insider-trades?owner_cik=1622769 returns every filing on this page — normalized, with footnotes and derivative legs — and webhooks push new filings to you in seconds. API docs →